The purpose of this study was to observe the microscopicchange of salivary gland tissues, which is the cause of xerostomia in diabetic condition; for this target, the author injected STZ 0.1mlIlOOgm b.w. on rat to produce diabetes, and then observed microscopic change in submandibular gland through the histopathologic method, obtaining as follows
1. All of the experimental specimens suffered diabetes after injection of STZ, but the blood glucose Ievel was irregular.
2. There were not interrelationship between the blood glucose level and microscopic change on salivary gland tissues.
3. The salivary gland changed after diabetes initiation in lapse of times; after 14 days, suffered severe destruction, however after 17 days, it was regenerated.
4. Salivary glands showed congested, destructive acim cells, and hyperplastic ductal cells as well as salivary gland duct-like structures.
5. There were accumulation of fat granules within, the cytoplasm of the acini cells on mucous gland in diabetic condition.
6. According to insulin injection, there were no more changes on salivary gland tissues, even in the accumulation of fat granules.
7. Histological changes of the serous gland were obvious more than the mucous gland in this experimental condition.
|